Bethel R A, Jansen R D, Heymsfield S B, Ansley J D, Hersh T, Rudman D
Am J Clin Nutr. 1979 May;32(5):1112-20. doi: 10.1093/ajcn/32.5.1112.
We performed nasogastric hyperalimentation with polyethylene catheters and appropriate feeding solutions in 12 cachectic patients who had been referred as candidates for central venous hyperalimentation. Most patients had primary gastrointestinal disease. The duration of hyperalimentation averaged 31 days. Seven patients obtained rapid weight gain (average 0.3 kg/day) with the nasogastric hyperalimentation alone. An additional two were successfully repleted with the addition of parenteral fluids via peripheral veins. In the nine repleted patients, serum albumin rose by average 19%, 24-hr urine creatinine by average 21%, and triceps skinfold by average 46%. The nature of the weight gain in the nine successful cases was analyzed by the metabolic balance study technique. Average composition of the increment in weight was: 50% protoplasm, 48% extracellular fluid, 19% adipose tissue, and less than 1% bone. We conclude that nasogastric hyperalimentation can replace central venous hyperalimentation in a substantial proportion of patients now receiving the latter type of treatment.
我们对12例被转诊为中心静脉高营养治疗候选者的恶病质患者，使用聚乙烯导管和合适的喂养溶液进行了鼻饲高营养治疗。大多数患者患有原发性胃肠道疾病。高营养治疗的持续时间平均为31天。7例患者仅通过鼻饲高营养治疗就实现了快速体重增加（平均每天0.3千克）。另外2例通过外周静脉补充胃肠外液体后成功康复。在9例康复患者中，血清白蛋白平均升高了19%，24小时尿肌酐平均升高了21%，肱三头肌皮褶厚度平均增加了46%。通过代谢平衡研究技术分析了9例成功病例中体重增加的性质。体重增加部分的平均组成如下：原生质50%，细胞外液48%，脂肪组织19%，骨骼不到1%。我们得出结论，在目前接受后一种治疗类型的相当一部分患者中，鼻饲高营养治疗可以替代中心静脉高营养治疗。
