Pinchcofsky-Devin G D, Kaminski M V
JPEN J Parenter Enteral Nutr. 1985 Jul-Aug;9(4):474-6. doi: 10.1177/0148607185009004474.
Periodic parenteral hyperalimentation, the interruption of feeding for a period of time each day, parallels the fasted vs fed state in the meal eater. The fasted state appears to be more physiologic and seems to be associated with an increase of visceral proteins. Intravenous hyperalimentation data that have been published seem to confirm this fact. The purpose of this study was to compare the effect of continuous enteral hyperalimentation and interrupt enteral hyperalimentation on the visceral protein compartment. Two groups of 10 afebrile matched control patients (group 1) were on continuous enteral hyperalimentation for 19 +/- 6 days with no improvement in serum albumin or serum transferrin levels. No changes were made in the feeding schedules of 10 of the patients. Feeding schedules of the other 10 patients were changed to an 8-hr interrupt enteral hyperalimentation with calories, protein, and volume being provided remaining the same. Repeat serum albumin and transferrin levels were obtained after 10 days. There was a significant increase in albumin and transferrin levels (p less than 0.005) in those patients changed to an interrupt feeding schedule.
定期胃肠外营养，即每天中断一段时间的喂养，类似于进食者的禁食与进食状态。禁食状态似乎更符合生理状态，且似乎与内脏蛋白增加有关。已发表的静脉高营养数据似乎证实了这一事实。本研究的目的是比较持续肠内高营养和间断肠内高营养对内脏蛋白区室的影响。两组各10名体温正常的匹配对照患者（第1组）接受持续肠内高营养19±6天，血清白蛋白或血清转铁蛋白水平无改善。其中10名患者的喂养计划未改变。另外10名患者的喂养计划改为8小时间断肠内高营养，提供的热量、蛋白质和量保持不变。10天后再次检测血清白蛋白和转铁蛋白水平。改为间断喂养计划的患者，其白蛋白和转铁蛋白水平显著升高（p<0.005）。
