Ahmad S, Bhanji A, Pal S, Karim M
Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK.
Int J Clin Pharmacol Ther. 2010 Aug;48(8):514-6. doi: 10.5414/cpp48514.
Non-steroidal anti-inflammatory drugs are known to have a number of potential side effects. Here we report a case demonstrating an uncommon complication, irreversible sensorineural deafness.
A 41-year-old man with pre-existing cardiac and renal dysfunction (for which his regular medications included furosemide) presumed secondary to a viral myocarditis developed acute sensorineural hearing loss 5 days after commencing treatment with indomethacin 25 mg tds for acute gout. His hearing loss was preceded by the development of tinnitus and failed to recover.
Permanent deafness is a rare but serious side effect of NSAIDs. Tinnitus developing in patients on these agents should be regarded as a potential warning sign of impending irreversible ototoxicity.
已知非甾体抗炎药有多种潜在副作用。在此，我们报告一例显示罕见并发症——不可逆性感音神经性耳聋的病例。
一名41岁男性，既往有心脏和肾功能不全（其常规用药包括速尿），推测继发于病毒性心肌炎，在开始用吲哚美辛25毫克每日三次治疗急性痛风5天后出现急性感音神经性听力损失。他在听力损失之前出现耳鸣，且听力未能恢复。
永久性耳聋是非甾体抗炎药罕见但严重的副作用。使用这些药物的患者出现耳鸣应被视为即将发生不可逆耳毒性的潜在警示信号。
