小眼畸形小鼠中的视网膜母细胞瘤蛋白

Retinoblastoma protein in microphthalmic mice.

作者信息

Richter J, Brylla E, Lenk C, Ernstberger J, Hilbig H

机构信息

Institute of Anatomy, University of Leipzig, Germany.

出版信息

Exp Toxicol Pathol. 2000 Mar;52(1):17-22. doi: 10.1016/S0940-2993(00)80009-3.

DOI:10.1016/S0940-2993(00)80009-3

PMID:10779148

Abstract

A microphthalmic strain of mice was used to study immunoresponse of the retinoblastoma protein. Comparing wild-type, heterozygote and homozygote microphthalmic eyes, we found an increasing labelling of phosphorylated retinoblastoma protein (pRb) in the retinal pigment epithelium. Additionally, microphthalmic eyes expressed pRb in the neuroepithelium. Especially rosettes were strongly labelled.

摘要

一种小眼畸形小鼠品系被用于研究视网膜母细胞瘤蛋白的免疫反应。比较野生型、杂合子和纯合子小眼畸形眼睛，我们发现视网膜色素上皮中磷酸化视网膜母细胞瘤蛋白（pRb）的标记增加。此外，小眼畸形眼睛在神经上皮中表达pRb。特别是菊形团被强烈标记。