Boner A L, Peroni D G, Piacentini G L, Venge P
Department of Pediatrics, University of Verona, Italy.
Clin Exp Allergy. 1993 Dec;23(12):1021-6. doi: 10.1111/j.1365-2222.1993.tb00294.x.
A cohort of 12 asthmatic children was followed over several months, during which they moved back and forth from an allergen-free to an allergen-rich environment at high and low altitude, respectively. The children were treated with non-steroidal anti-asthmatic drugs as clinically needed. Histamine PC20-FEV1 was unaltered during the study period, whereas serum levels of eosinophil cationic protein (ECP) and eosinophil protein X (EPX) showed significant changes when the children were exposed to the offending allergens. The total IgE significantly increased during exposure. The serum levels of myeloperoxidase (MPO) as well as of chemotactic factors for both neutrophils and eosinophils were unaltered during allergen exposure. We conclude that the serum markers of eosinophil activity ECP and EPX are sensitive indices of allergen exposure in asthmatic atopic children.
对一组12名哮喘儿童进行了数月的跟踪研究，在此期间，他们分别在高海拔和低海拔地区在无过敏原环境和富含过敏原的环境之间来回移动。根据临床需要，用非甾体类抗哮喘药物对这些儿童进行治疗。在研究期间，组胺PC20-FEV1未发生变化，而当儿童暴露于有害过敏原时，嗜酸性粒细胞阳离子蛋白（ECP）和嗜酸性粒细胞蛋白X（EPX）的血清水平出现了显著变化。暴露期间总IgE显著增加。在过敏原暴露期间，髓过氧化物酶（MPO）以及中性粒细胞和嗜酸性粒细胞趋化因子的血清水平未发生变化。我们得出结论，嗜酸性粒细胞活性的血清标志物ECP和EPX是哮喘特应性儿童过敏原暴露的敏感指标。
