Razavi Zahra Sadat, Asgarpour Kasra, Mahjoubin-Tehran Maryam, Rasouli Susan, Khan Haroon, Shahrzad Mohammad Karim, Hamblin Michael R, Mirzaei Hamed
School of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
Department of Medicine, University of Western Ontario, London, ON, Canada.
Mol Ther Oncolytics. 2021 May 15;21:220-241. doi: 10.1016/j.omto.2021.04.002. eCollection 2021 Jun 25.
Gastrointestinal (GI) cancers are among the main reasons for cancer death globally. The deadliest types of GI cancer include colon, stomach, and liver cancers. Multiple lines of evidence have shown that angiogenesis has a key role in the growth and metastasis of all GI tumors. Abnormal angiogenesis also has a critical role in many non-malignant diseases. Therefore, angiogenesis is considered to be an important target for improved cancer treatment. Despite much research, the mechanisms governing angiogenesis are not completely understood. Recently, it has been shown that angiogenesis-related non-coding RNAs (ncRNAs) could affect the development of angiogenesis in cancer cells and tumors. The broad family of ncRNAs, which include long non-coding RNAs, microRNAs, and circular RNAs, are related to the development, promotion, and metastasis of GI cancers, especially in angiogenesis. This review discusses the role of ncRNAs in mediating angiogenesis in various types of GI cancers and looks forward to the introduction of mimetics and antagonists as possible therapeutic agents.
胃肠道（GI）癌症是全球癌症死亡的主要原因之一。最致命的胃肠道癌症类型包括结肠癌、胃癌和肝癌。多项证据表明，血管生成在所有胃肠道肿瘤的生长和转移中起关键作用。异常血管生成在许多非恶性疾病中也起关键作用。因此，血管生成被认为是改善癌症治疗的重要靶点。尽管进行了大量研究，但血管生成的调控机制尚未完全明确。最近有研究表明，血管生成相关的非编码RNA（ncRNAs）可影响癌细胞和肿瘤中血管生成的发展。ncRNAs大家族，包括长链非编码RNA、微小RNA和环状RNA，与胃肠道癌症的发生、发展和转移有关，尤其是在血管生成方面。本文综述了ncRNAs在介导各类胃肠道癌症血管生成中的作用，并期待引入模拟物和拮抗剂作为可能的治疗药物。
