Makedonov G P, Tskhovrebova L V, Semiachkina A N, Zasukhina G D
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Genetika. 2000 Mar;36(3):393-8.
The radioadaptive response was assessed by the chromosome aberration test in lymphocytes of humans with hereditary diseases of connective tissue, which were earlier characterized as repair-deficient: Marfan syndrome (SM), Elers-Danlos syndrome (E-D), and homocystinurea (HCU). The radioadaptive response was observed in cells of patients with Marfan syndrome and Elers-Danlos syndrome but not in cells of patients with homocystinurea. Parameters of cell protection against gamma-irradiation at radioadaptive response were similar to those obtained in cells pretreated with interferon. These data indicate, first, the possibility that repair pathways and the radioadaptive response are independent and second, that there are common pathways of protection upon radioadaptive response and the antimutagenic action of interferon.
通过染色体畸变试验，在患有结缔组织遗传病的人类淋巴细胞中评估辐射适应性反应，这些患者先前被确定为修复缺陷型：马凡综合征（SM）、埃勒斯-当洛综合征（E-D）和同型胱氨酸尿症（HCU）。在马凡综合征和埃勒斯-当洛综合征患者的细胞中观察到了辐射适应性反应，但在同型胱氨酸尿症患者的细胞中未观察到。辐射适应性反应时细胞对γ射线照射的保护参数与用干扰素预处理的细胞中获得的参数相似。这些数据首先表明修复途径和辐射适应性反应可能是独立的，其次表明在辐射适应性反应和干扰素的抗诱变作用中存在共同的保护途径。
