Dubovaia T K, Tsibulevskiĭ A Iu, Deev A I, Sergeev A I, Bykov A V, Evstaf'eva N Ia, Semushin B V
Russian State Medical University, Moscow, Russia.
Izv Akad Nauk Ser Biol. 2000 Mar-Apr(2):158-63.
Organism intoxication with tetrachloromethane induces a complex of transformations in the liver and serum albumins system manifested in the liver as necroses in the central lobe, dilatation of sinus capillaries and blood stasis in them, increased content of total water, and changed magneto-relaxation properties indicating decreased structurization of water. The system of serum albumins shows decreased total concentration of albumins in the serum, decreased constant of 1-(phenylamino)-8-sulfonaphthalene probe binding, increased mean number of probe binding per albumin molecule, and increased accessibility of probe in the protein-probe complex for the quencher indicating changed type of interaction between the protein and fluorescent probe. Introduction of a antihypoxant, antioxidant, or actoprotector has a positive effect on the condition of the liver and serum albumins system: The studied indices are nearly completely normalized.
四氯化碳中毒会引发肝脏和血清白蛋白系统的一系列复杂变化，在肝脏中表现为中央叶坏死、窦状毛细血管扩张及其中的血液淤滞、总含水量增加，以及磁弛豫特性改变，表明水的结构化程度降低。血清白蛋白系统表现为血清中白蛋白总浓度降低、1-（苯氨基）-8-磺基萘探针结合常数降低、每个白蛋白分子的探针结合平均数增加，以及蛋白质-探针复合物中探针对于猝灭剂的可及性增加，表明蛋白质与荧光探针之间的相互作用类型发生了改变。引入抗低氧剂、抗氧化剂或抗疲劳保护剂对肝脏和血清白蛋白系统的状况有积极影响：所研究的指标几乎完全恢复正常。
