质子磁共振波谱测量的胆碱水平与胶质瘤中Ki-67标记指数的相关性。
Correlation between choline level measured by proton MR spectroscopy and Ki-67 labeling index in gliomas.
作者信息
Shimizu H, Kumabe T, Shirane R, Yoshimoto T
机构信息
Department of Neurosurgery, Kohnan Hospital, Sendai, Japan.
出版信息
AJNR Am J Neuroradiol. 2000 Apr;21(4):659-65.
BACKGROUND AND PURPOSE
The clinical relevance of proton MR spectroscopy needs further clarification as to its usefulness and limitations. The purpose of this study was to investigate the correlation between the semiquantitative choline-containing compound level (Cho value) measured by MR spectroscopy and the Ki-67 labeling index in gliomas.
METHODS
Localized proton spectra were obtained in 26 consecutive patients with glioma who subsequently underwent surgery for tumor removal. Metabolic values in the spectra were measured semiquantitatively using an external standard of reference. The Ki-67 labeling index was measured in the surgical specimen. Because the semiquantitative metabolic values may be affected by tissue components included in the spectroscopic voxel, the MR imaging appearance of the voxel within the tumor was classed as homogeneous or heterogeneous through visual evaluation of the presence of necrosis, cyst, hemorrhage, and calcification, and pattern of enhancement.
RESULTS
We found a strong linear correlation between the Cho value and the Ki-67 labeling index in the 18 homogeneous gliomas, but no correlation was found in the eight heterogeneous gliomas, which turned out to be malignant.
CONCLUSION
The semiquantitative Cho value is a reliable predictor of proliferative activity of gliomas when the tumor appears homogeneous on MR images.
背景与目的
质子磁共振波谱的临床相关性，在其有用性和局限性方面仍需进一步阐明。本研究的目的是探讨磁共振波谱测量的半定量含胆碱化合物水平（Cho值）与胶质瘤中Ki-67标记指数之间的相关性。
方法
对26例连续的胶质瘤患者进行局部质子波谱分析，这些患者随后接受了肿瘤切除手术。使用外部参考标准对波谱中的代谢值进行半定量测量。在手术标本中测量Ki-67标记指数。由于半定量代谢值可能受波谱体素内组织成分的影响，通过视觉评估坏死、囊肿、出血、钙化的存在以及强化模式，将肿瘤内体素的磁共振成像表现分为均匀或不均匀。
结果
我们发现18例均匀性胶质瘤的Cho值与Ki-67标记指数之间存在强线性相关性，但在8例不均匀性胶质瘤（结果为恶性）中未发现相关性。
结论
当肿瘤在磁共振图像上表现为均匀时，半定量Cho值是胶质瘤增殖活性的可靠预测指标。
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