Quereux C, Gelas B, Chevallier T, Petit F, Micheletti M C
Service de gynécologie-obstétrique, CHU de Reims, France.
Gynecol Obstet Fertil. 2000 Mar;28(3):238-44.
To assess efficacy and speed of action of a monodose sertaconazole vaginal suppository administered as a single treatment or combined with sertaconazole cream applied to the vulvar area.
This prospective, multicentric, randomised open study was conducted on 77 women with vulvovaginal candidiasis confirmed by mycological examination. They were either treated with one sertaconazole monodose vaginal suppository only (group O) or treated with the suppository combined with sertaconazole cream applied to the vulvar area for 7 days (group OC). The patients who were not clinically cured at D7 received a second phase of treatment.
Clinical cure rates were higher in group OC than in group O at D7 (76% versus 68%), and D14 (100% versus 80%). The efficacy on symptoms was faster in group OC, with 78% of the patients relieved of pruritus as early as D2 versus 61% in group O, although these differences were not significant. Clinical local tolerance was very good, with 95% of patients not experiencing any local side effects.
When candidiasis is both vulvar and vaginal, the combination of sertaconazole cream with a monodose sertaconazole vaginal suppository tends to improve clinical cure at D7 and D14 and to relieve more patients as early as D2 than the vaginal suppository used as a single treatment.
评估单剂量舍他康唑阴道栓剂单独治疗或联合舍他康唑乳膏用于外阴区域的疗效及起效速度。
对77名经真菌学检查确诊为外阴阴道念珠菌病的女性进行了这项前瞻性、多中心、随机开放研究。她们要么仅接受一剂舍他康唑阴道栓剂治疗（O组），要么接受该栓剂联合舍他康唑乳膏用于外阴区域治疗7天（OC组）。在第7天未临床治愈的患者接受第二阶段治疗。
在第7天（76%对68%）和第14天（100%对80%），OC组的临床治愈率高于O组。OC组症状缓解更快，早在第2天就有78%的患者瘙痒缓解，而O组为61%，尽管这些差异不显著。临床局部耐受性非常好，95%的患者未出现任何局部副作用。
当念珠菌病累及外阴和阴道时，与单独使用阴道栓剂治疗相比，舍他康唑乳膏联合单剂量舍他康唑阴道栓剂在第7天和第14天的临床治愈率更高，且早在第2天就能使更多患者症状缓解。
