Tarpley J L, Potvin C, Chretien P B
Cancer. 1975 Mar;35(3):638-44. doi: 10.1002/1097-0142(197503)35:3<638::aid-cncr2820350315>3.0.co;2-o.
Immune competence was evaluated in cured patients who had been treated by irradiation for carcinoma of the laryngopharynx, and compared with that of similar patients treated by surgery alone, and normal controls. Cellular immunity was determined by quantitation of in vitro phytohemagglutinin (PHA)-induced lymphocyte reactivity and peripheral blood thymus-dependent lymphocyte (T cell) levels. Humoral immunity was assessed by measurement of serum immunoglobulin levels and by the effect of serum on in vitro normal lymphocyte reactivity to PHA. In 21 patients who were studied for 4-23 years (mean 8.4) after surgical treatment alone for laryngopharyngeal carcinoma, neither cellular nor humoral immunity differed from that of 44 controls. In contrast, 14 patients who had been irradiated and subsequently cured for 4-15 years (mean 9.0) prior to evaluation displayed significantly impaired cellular immune competence when compared to normals and patients treated by surgery alone. Since previous determinations of the effects of radiation therapy have been in patients who received irratiation to the thymic region or large area of bone marrow, this study indicates that radiation therapy for cancer administered via portals that encompass a minimal area of the immune system may be associated with prolonged impairment of cellular immunity.
对曾接受过放射治疗的下咽癌治愈患者的免疫能力进行了评估，并与仅接受手术治疗的类似患者以及正常对照组进行了比较。通过定量体外植物血凝素（PHA）诱导的淋巴细胞反应性和外周血胸腺依赖性淋巴细胞（T细胞）水平来确定细胞免疫。通过测量血清免疫球蛋白水平以及血清对体外正常淋巴细胞对PHA反应性的影响来评估体液免疫。在21例接受下咽癌单纯手术治疗后接受了4至23年（平均8.4年）研究的患者中，细胞免疫和体液免疫均与44例对照组无异。相比之下，在评估前接受过放疗并随后治愈了4至15年（平均9.0年）的14例患者，与正常人和仅接受手术治疗的患者相比，其细胞免疫能力明显受损。由于先前对放射治疗效果的测定是在接受胸腺区域或大面积骨髓照射的患者中进行的，因此本研究表明，通过包含最小免疫系统区域的门静脉进行的癌症放射治疗可能与细胞免疫的长期损害有关。
