Sabik J F, Lytle B W, Blackstone E H, McCarthy P M, Loop F D, Cosgrove D M
Department of Thoracic and Cardiovascular Surgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. sabikj2ccf.org
J Thorac Cardiovasc Surg. 2000 May;119(5):946-62. doi: 10.1016/S0022-5223(00)70090-0.
To evaluate long-term effectiveness of a strategy for managing the aortic root and distal aorta according to the pathology in ascending aortic dissection.
From 1978 to 1995, 208 patients underwent operations for acute (n = 135) and chronic (n = 73) ascending aortic dissection. Surgical strategies included valve resuspension with supracoronary aortic root repair and ascending aortic graft for normal sinuses and valve (n = 135), composite valve and ascending aortic graft for abnormal sinuses and valve (n = 47), and valve replacement and supracoronary ascending aortic graft for normal sinuses and abnormal valve (n = 26). Resection extended into the arch only if the intimal tear originated in or extended to the aortic arch (n = 31).
Hospital mortality was 14%. Cardiogenic shock (P =.002) and concomitant coronary artery bypass grafting (P =.001) were associated with increased risk; use of circulatory arrest (P =.0003) decreased risk. Survival was 87%, 68%, and 52% at 30 days, 5 years, and 10 years, respectively. Advanced age, earlier date of operation, composite graft, and arch resection were associated with decreased survival; residual distal dissected aorta was not. Reoperation was required for 5 proximal and 8 distal problems.
In both acute and chronic ascending aortic dissections, (1) circulatory arrest is associated with low early mortality; (2) with normal sinuses and valve, supracoronary repair of the dissected aortic root and valve resuspension is effective long term; and (3) residual distal dissected aorta does not decrease late survival and has a low risk of aneurysmal change and reoperation for at least 10 years.
根据升主动脉夹层的病理情况评估一种主动脉根部和远端主动脉管理策略的长期效果。
1978年至1995年,208例患者接受了急性(n = 135)和慢性(n = 73)升主动脉夹层手术。手术策略包括对于正常窦和瓣膜采用冠状动脉上主动脉根部修复及升主动脉移植并瓣膜再悬吊(n = 135),对于异常窦和瓣膜采用复合瓣膜及升主动脉移植(n = 47),对于正常窦和异常瓣膜采用瓣膜置换及冠状动脉上升主动脉移植(n = 26)。仅当内膜撕裂起源于或延伸至主动脉弓时(n = 31),切除范围才扩展至主动脉弓。
医院死亡率为14%。心源性休克(P = 0.002)和同期冠状动脉搭桥术(P = 0.001)与风险增加相关;使用体外循环(P = 0.0003)可降低风险。30天、5年和10年的生存率分别为87%、68%和52%。高龄、手术日期较早、复合移植和主动脉弓切除与生存率降低相关;残余远端夹层主动脉则不然。5例近端问题和8例远端问题需要再次手术。
在急性和慢性升主动脉夹层中,(1)体外循环与较低的早期死亡率相关;(2)对于正常窦和瓣膜,冠状动脉上修复夹层主动脉根部及瓣膜再悬吊长期有效;(3)残余远端夹层主动脉不会降低晚期生存率,至少10年内动脉瘤样改变和再次手术的风险较低。