Wang Zhengjun, Greason Kevin L, Pochettino Alberto, Schaff Hartzell V, Suri Rakesh M, Stulak John M, Dearani Joseph A
Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn; Department of Cardiovascular Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, China.
Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minn.
J Thorac Cardiovasc Surg. 2014 Nov;148(5):2117-22. doi: 10.1016/j.jtcvs.2013.12.059. Epub 2014 Jan 15.
Limited long-term outcome data are available on survival and the need for aortic root or valve reoperation after surgery for acute ascending aorta dissection. We report our 42-year experience.
We reviewed the records of 269 patients who had undergone surgery for acute ascending aorta dissection from July 1969 to June 2011. The mean age at surgery was 62.1±15.2 years, and 181 were men (67.3%). The distal operation was limited to hemiarch replacement. The proximal aortic operation groups included a composite valve conduit in 66 patients (24.5%), aortic root repair in 112 (41.6%), and isolated supracoronary ascending aorta replacement in 91 (33.8%).
Operative morbidity occurred in 224 patients (83.3%) and mortality in 44 (16.4%), with similar rates among the groups (P=.894 and P=.466, respectively). The mean follow-up was 9.7±7.5 years. The Kaplan-Meier survival estimate at 10 and 20 years was 65.5%±3.6% and 28.7%±4.3%, respectively, and was similar among the groups (P=.227). Reoperation on the aortic root or valve occurred in 20 patients (8.9%) at a median of 6.8 years (range, 0.2-20.3). The freedom from reoperation rate at 10 and 20 years was 91.5%±2.3% and 79.3%±6.1%, respectively, with no difference among the groups (P=.605).
Operative morbidity and mortality rates are significant after repair of acute ascending aorta dissection. Aortic root surgery can be performed without an apparent increase in the prevalence of operative morbidity or mortality; however, patients remain at risk of subsequent aortic root or valve surgery.
关于急性升主动脉夹层手术后的生存情况以及主动脉根部或瓣膜再次手术需求的长期结局数据有限。我们报告我们42年的经验。
我们回顾了1969年7月至2011年6月期间接受急性升主动脉夹层手术的269例患者的记录。手术时的平均年龄为62.1±15.2岁,男性181例(67.3%)。远端手术仅限于半弓置换。近端主动脉手术组包括66例(24.5%)患者采用复合瓣膜管道、112例(41.6%)患者进行主动脉根部修复以及91例(33.8%)患者进行单纯升主动脉冠状动脉上方置换。
224例患者(83.3%)发生手术并发症,44例(16.4%)死亡,各手术组之间发生率相似(分别为P = 0.894和P = 0.466)。平均随访时间为9.7±7.5年。10年和20年的Kaplan-Meier生存估计分别为65.5%±3.6%和28.7%±4.3%,各手术组之间相似(P = 0.227)。20例患者(8.9%)进行了主动脉根部或瓣膜再次手术,中位时间为6.8年(范围0.2 - 20.3年)。10年和...(此处原文似乎不完整)20年无再次手术率分别为91.5%±2.3%和79.3%±6.1%,各手术组之间无差异(P = 0.605)。
急性升主动脉夹层修复术后手术并发症和死亡率较高。主动脉根部手术可在不明显增加手术并发症或死亡率发生率的情况下进行;然而,患者仍有后续进行主动脉根部或瓣膜手术的风险。