Sachdev P, Brodaty H, Rose N, Cathcart S
School of Psychiatry, University of New South Wales, Neuropsychiatric Institute, Prince of Wales Hospital, Sydney.
Br J Psychiatry. 1999 Nov;175:416-21. doi: 10.1192/bjp.175.5.416.
Late-onset schizophrenia (LOS) may have a basis in age-related coarse brain disease, but empirical support for this is conflicting.
Is LOS characterised by more neurological disease than early-onset schizophrenia (EOS)?
DSM-III-R-defined LOS subjects (n = 27) were compared with 30 EOS and 34 volunteer control subjects on neurological status, neuropsychological test performance and brain magnetic resonance imaging (MRI).
LOS and EOS groups had more 'soft' neurological signs and drug-induced movement abnormalities, and performed more poorly on tests assessing speed of information processing, memory and frontal executive functioning. On MRI, the LOS and EOS groups had greater lateral ventricular size than the control group. The LOS subjects also had more signal hyperintensities in periventricular white matter and subcortical nuclei than controls.
LOS and EOS subjects were very similar on neuropsychological, neurological and structural neuroimaging parameters, except that there were more MRI periventricular hyperintensities in LOS subjects.
迟发性精神分裂症（LOS）可能与年龄相关的脑器质性疾病有关，但对此的实证支持存在矛盾。
与早发性精神分裂症（EOS）相比，LOS是否以更多的神经疾病为特征？
将DSM-III-R定义的LOS受试者（n = 27）与30名EOS受试者和34名志愿者对照受试者进行比较，比较内容包括神经状态、神经心理测试表现和脑磁共振成像（MRI）。
LOS组和EOS组有更多的“软性”神经体征和药物引起的运动异常，在评估信息处理速度、记忆和额叶执行功能的测试中表现更差。在MRI上，LOS组和EOS组的侧脑室大小均大于对照组。LOS受试者在脑室周围白质和皮质下核中的信号高增强也比对照组更多。
LOS受试者和EOS受试者在神经心理、神经和结构神经影像学参数方面非常相似，只是LOS受试者的MRI脑室周围高增强更多。
