Tampi Rajesh R, Young Juan, Hoq Rakin, Resnick Kyle, Tampi Deena J
Department of Psychiatry and Behavioral Sciences, Cleveland Clinic Akron General, Akron, OH 44307, USA.
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Ther Adv Psychopharmacol. 2019 Oct 16;9:2045125319882798. doi: 10.1177/2045125319882798. eCollection 2019.
Psychotic disorders are not uncommon in late life. These disorders often have varied etiologies, different clinical presentations, and are associated with significant morbidity and mortality among the older adult population. Psychotic disorders in late life develop due to the complex interaction between various biological, psychological, social, and environmental factors. Given the significant morbidity and mortality associated with psychotic disorders in late life, a comprehensive work-up should be conducted when they are encountered. The assessment should not only identify the potential etiologies for the psychotic disorders, but also recognize factors that predicts possible outcomes for these disorders. Treatment approaches for psychotic disorders in late life should include a combination of nonpharmacological management strategies with the judicious use of psychotropic medications. When antipsychotic medications are necessary, they should be used cautiously with the goal of optimizing outcomes with regular monitoring of their efficacy and adverse effects.
精神病性障碍在老年期并不罕见。这些障碍通常病因各异，临床表现不同，并且在老年人群中与显著的发病率和死亡率相关。老年期的精神病性障碍是由各种生物、心理、社会和环境因素之间的复杂相互作用所致。鉴于老年期精神病性障碍相关的显著发病率和死亡率，遇到这些障碍时应进行全面检查。评估不仅应确定精神病性障碍的潜在病因，还应识别预测这些障碍可能结局的因素。老年期精神病性障碍的治疗方法应包括非药物管理策略与谨慎使用精神药物相结合。当需要使用抗精神病药物时，应谨慎使用，目标是通过定期监测其疗效和不良反应来优化治疗效果。
