Hassan K, Cowan F J, Jenkins H R
Department of Child Health, University Hospital of Wales, Heath Park, Cardiff, UK.
Eur J Pediatr. 2000 Apr;159(4):261-3. doi: 10.1007/s004310050066.
A prospective study was undertaken throughout Wales over the period from 1 January 1995 to 30 March 1997, to determine the incidence of childhood inflammatory bowel disease (IBD). Thirty-eight (24 male) new cases of IBD were reported. Twenty (16 male) of the reported cases had Crohn's disease, 11 (5 male) had ulcerative colitis (UC) and 7 (3 male) indeterminate colitis. Crohn's disease occurred four times more often in boys than girls, whereas there was no sex difference in the incidence for UC and indeterminate colitis. The median age at presentation was 12 (range 1.5-16) years and there was no difference in the age of presentation or the duration of symptoms prior to diagnosis in any of the types of IBD.
The overall incidence (95% confidence intervals) for IBD in Wales was 2.6 (1.87-3.48) cases per 100,000 per year. The incidence for Crohn's disease was 1.36 (0.86-2.04) cases per 100,000 per year, for UC 0.75 (0.39-1.28) cases per 100,000 per year and for indeterminate colitis 0.48 (0.2-0.92) cases per 100,000 per year.
1995年1月1日至1997年3月31日期间在威尔士开展了一项前瞻性研究，以确定儿童炎症性肠病（IBD）的发病率。报告了38例（24例男性）IBD新病例。报告病例中20例（16例男性）患有克罗恩病，11例（5例男性）患有溃疡性结肠炎（UC），7例（3例男性）患有不确定性结肠炎。克罗恩病在男孩中的发病率是女孩的四倍，而UC和不确定性结肠炎的发病率在性别上没有差异。发病时的中位年龄为12岁（范围1.5 - 16岁），在任何类型的IBD中，发病年龄或诊断前症状持续时间均无差异。
威尔士IBD的总体发病率（95%置信区间）为每年每10万人2.6例（1.87 - 3.48）。克罗恩病的发病率为每年每10万人1.36例（0.86 - 2.04），UC为每年每10万人0.75例（0.39 - 1.28），不确定性结肠炎为每年每10万人0.48例（0.2 - 0.92）。
