Coutureau E, Galani R, Jarrard L E, Cassel J C
Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 ULP/CNRS, Strasbourg, France.
Exp Brain Res. 2000 Apr;131(3):381-92. doi: 10.1007/s002219900301.
Using adult Long-Evans male rats, this experiment compared spontaneous (assessed 15 days and 4.5 months after surgery) and amphetamine-induced (assessed from 4.5 months after surgery onwards; 1 mg/kg, i.p., ten injections, 48 h apart) locomotor activity following N-methyl-D-aspartate lesions of the entorhinal cortex, electrolytic lesions of the fimbria-fornix, or ibotenate lesions of the hippocampus. Sham-operated rats were used as controls. Hippocampal and fimbria-fornix lesions, but not entorhinal-cortex lesions induced diurnal and nocturnal hyperactivity, which was attenuated over time, but only in rats with fimbria-fornix lesions. Amphetamine-induced hyperlocomotion was assessed in a familiar environment. Lesions of the entorhinal cortex potentiated the locomotor effects of amphetamine, but not lesions of the hippocampus or interruption of the axons in the fimbria-fornix pathway. Sensitization appeared to be decreased by fimbria-fornix lesions and to be prevented by hippocampal lesions. Rats with entorhinal-cortex lesions behaved as if they had already been sensitized by the lesion. These results clearly show that lesions of the fimbria-fornix, the hippocampus, and of the entorhinal cortex have different effects on spontaneous and amphetamine-induced hyperactivity, as they also have on learning and memory tasks.
本实验使用成年雄性Long-Evans大鼠，比较了内嗅皮质N-甲基-D-天冬氨酸损伤、穹窿海马伞电解损伤或海马鹅膏蕈氨酸损伤后自发的（在手术后15天和4.5个月评估）以及苯丙胺诱导的（从手术后4.5个月开始评估；1毫克/千克，腹腔注射给药，共十次注射，每次间隔48小时）运动活动。假手术大鼠用作对照。海马和穹窿海马伞损伤而非内嗅皮质损伤会导致昼夜活动亢进，且这种亢进随时间减弱，但仅在穹窿海马伞损伤的大鼠中出现这种情况。苯丙胺诱导的运动亢进是在熟悉的环境中评估的。内嗅皮质损伤增强了苯丙胺的运动效应，但海马损伤或穹窿海马伞通路轴突中断则不会。穹窿海马伞损伤似乎会降低敏化作用，而海马损伤则可防止敏化作用出现。内嗅皮质损伤的大鼠表现得就好像它们已经因损伤而产生了敏化作用。这些结果清楚地表明，穹窿海马伞、海马和内嗅皮质的损伤对自发的和苯丙胺诱导的活动亢进具有不同影响，但对学习和记忆任务也有不同影响。
