Haskovec C, Angelisová P
Folia Biol (Praha). 1975;21(1):15-9.
Responsiveness of spleen and lymph node lymphocytes to in vitro stimulation by phytohaemagglutinin was investigated in several mouse strains. Considerable interstain differences in RNA and DNA synthesis were found both for PHA-stimulated and unstimulated cells; the latter component thus tends to contribute to the observed over-all differences in lymphocyte responsiveness to "specific" stimulation. Of the tested strains and F-1 HYBRIDS, THE HIGHEST RESPONDERS WERE A/Ph, its F-1 hybrids with a few other strains and BALB/C. The possibility that the interstrain differences in the rate of nucleic acid synthesis and hence in lymphocyte responsiveness could be due to different sensitivity of the lymphocytes to experimental treatment was not confirmed experimentally. Relatively high rate of synthesis of nucleic acids in PHA unstimulated cells and its great interstrain variation is interpreted in terms of variation in "spontaneous" transformability.
在几种小鼠品系中研究了脾脏和淋巴结淋巴细胞对植物血凝素体外刺激的反应性。对于经植物血凝素刺激和未经刺激的细胞，在RNA和DNA合成方面均发现了品系间的显著差异；因此，后一成分往往导致观察到的淋巴细胞对“特异性”刺激反应性的总体差异。在测试的品系和F-1杂种中，反应性最高的是A/Ph品系、它与其他几个品系的F-1杂种以及BALB/C品系。淋巴细胞对实验处理的不同敏感性可能导致核酸合成速率以及淋巴细胞反应性的品系间差异，这一可能性未得到实验证实。植物血凝素未刺激细胞中核酸合成速率相对较高及其在品系间的巨大差异，根据“自发”转化能力的差异进行了解释。
