H-2同源小鼠品系中，伴刀豆球蛋白A（Con A）和植物血凝素（PHA）刺激的淋巴结细胞对[3H]胸腺嘧啶核苷摄取的差异。
Differences in [3H]-thymidine uptake of lymph node cells stimulated by Con A and PHA in H-2 congenic mouse strains.
作者信息
Bösze Z, Mérei J, Fachet J
出版信息
Immunology. 1979 Jun;37(2):447-52.
The genetic control of the lymphocyte responsiveness to Con A and PHA-P has been studied by using inbred, H-2 congenic mouse strains. Segregation studies were carried out on F1 and backcross mice of a high and a low responder strain. According to the results, there is a strong correlation between the responsiveness of lymph node cells to mitogens and H-2 haplotypes in different H-2 congenic strains of mice and in different backcross generations. High responsiveness to PHA-P is associated with H-2b, while low responsiveness with H-2a or H-2k haplotypes, but the correlation is the inverse in response to Con A, in the parental strains and backcross mice as well. The magnitude of the responses to both Con A and PHA-P was found to be intermediate in F1 heterozygotes of a low and high responder parental strain. The effect of other non H-2 genes on the responsiveness to these mitogens has also been demonstrated.
通过使用近交的、H-2同源基因小鼠品系，对淋巴细胞对刀豆蛋白A（Con A）和植物血凝素-P（PHA-P）的反应性的遗传控制进行了研究。对一个高反应性品系和一个低反应性品系的F1代和回交小鼠进行了分离研究。根据结果，在不同的H-2同源基因小鼠品系和不同的回交世代中，淋巴结细胞对有丝分裂原的反应性与H-2单倍型之间存在很强的相关性。对PHA-P的高反应性与H-2b相关，而低反应性与H-2a或H-2k单倍型相关，但在亲本品系和回交小鼠中，对Con A的反应相关性则相反。在低反应性和亲本高反应性品系的F1杂合子中，对Con A和PHA-P的反应强度均为中等。还证明了其他非H-2基因对这些有丝分裂原反应性的影响。
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