Miller T E, Scott L, Simpson G, Ormrod D J
Clin Exp Immunol. 1976 Jun;24(3):492-500.
The lymphocytic infiltrate in the renal parenchyma is a consistent histological feature of pyelonephritis, but the role of the lymphocytes in the immunobiology of pyelonephritis is not known. In this investigation the influence of the local environment on the potential function of T lymphocytes in the kidney was investigated. The experiments have demonstrated that the response of rat lymphocytes to stimulation in vitro with phytohaemagglutinin (PHA) can be entirely ablated by normal kidney cells. Even when the number of kidney cells added to cultures of lymphocytes was less than 2% of the cells present some ablation of T-lymphocyte function could be detected. The biological characteristics of the factor causing ablation of the PHA responsiveness of T lymphocytes were partially characterized and the factor appears to have unique features that differentiate it from lymphocyte chalones and other tissue factors influencing lymphocyte function. The results may explain recent findings where T lymphocytes were found to be the predominant lymphocyte in the inflammatory infiltrate but were not responsive to PHA in vitro.
肾实质中的淋巴细胞浸润是肾盂肾炎一致的组织学特征，但淋巴细胞在肾盂肾炎免疫生物学中的作用尚不清楚。在本研究中，研究了局部环境对肾内T淋巴细胞潜在功能的影响。实验表明，正常肾细胞可完全消除大鼠淋巴细胞对体外植物血凝素（PHA）刺激的反应。即使添加到淋巴细胞培养物中的肾细胞数量少于现存细胞的2%，也能检测到T淋巴细胞功能的部分消除。对导致T淋巴细胞PHA反应性消除的因子的生物学特性进行了部分表征，该因子似乎具有独特的特征，使其有别于淋巴细胞抑素和其他影响淋巴细胞功能的组织因子。这些结果可能解释了最近的发现，即T淋巴细胞是炎症浸润中的主要淋巴细胞，但在体外对PHA无反应。
