在健康的巴西成年人中，感染多种不同基因型的TT病毒毒株是常见现象。
Coinfection with multiple TT virus strains belonging to different genotypes is a common event in healthy Brazilian adults.
作者信息
Niel C, Saback F L, Lampe E
机构信息
Department of Virology, Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
出版信息
J Clin Microbiol. 2000 May;38(5):1926-30. doi: 10.1128/JCM.38.5.1926-1930.2000.
Abstract
Testing of the DNA of TT virus (TTV) was done with serum samples obtained from 191 persons working in a public hospital of the city of Rio de Janeiro, Brazil. TTV DNA was detected by PCR in the sera of 125 (65.4%) individuals. PCR products were cloned, and sequences with a length of 159 bases surrounding the TATA signal region were determined for 100 clones derived from 31 individuals. One clone from each of 23 subjects was sequenced, while 7 to 19 clones from eight individuals were sequenced. None of the sera contained a viral sequence identical to that of any other individual. Phylogenetic analysis revealed the existence of a divergent TTV genotype possessing a single-base deletion at position 140. Among the eight persons for whom various sequences were analyzed, six were coinfected with between two and seven TTV strains belonging to different genotypes. The results suggest that coinfection with multiple TTV strains belonging to different genotypes is a common event in healthy Brazilian adults.
摘要
对来自巴西里约热内卢市一家公立医院的191名工作人员的血清样本进行了TT病毒（TTV）DNA检测。通过聚合酶链反应（PCR）在125名（65.4%）个体的血清中检测到了TTV DNA。PCR产物被克隆，并对来自31名个体的100个克隆测定了围绕TATA信号区域的长度为159个碱基的序列。对23名受试者中的每一名的一个克隆进行了测序，同时对8名个体的7至19个克隆进行了测序。没有一份血清含有与其他任何个体相同的病毒序列。系统发育分析揭示了存在一种在第140位有单碱基缺失的不同的TTV基因型。在对其多种序列进行分析的8人中，有6人同时感染了2至7种属于不同基因型的TTV毒株。结果表明，在健康的巴西成年人中，同时感染多种不同基因型的TTV毒株是常见现象。
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