一种TT病毒变体（分离株名称为SANBAN）的完整环状DNA基因组以及44个部分ORF2序列，这表明其多样性程度远超基因型。

Complete circular DNA genome of a TT virus variant (isolate name SANBAN) and 44 partial ORF2 sequences implicating a great degree of diversity beyond genotypes.

作者信息

Hijikata M, Takahashi K, Mishiro S

机构信息

Department of Medical Sciences, Toshiba General Hospital, 6-3-22 Higashi Oh-i, Shinagawa-ku, Tokyo, 140-8522, Japan.

出版信息

Virology. 1999 Jul 20;260(1):17-22. doi: 10.1006/viro.1999.9797.

DOI:10.1006/viro.1999.9797

PMID:10405352

Abstract

Information on the entire genome of TT virus (TTV) has been scarce. The circular ssDNA genome of a variant (isolate name SANBAN) that we sequenced was only 56.7% homologous to the prototype isolate (TA278), with even lower homology at the amino acid level: 34.2% for ORF1 and 39.7% for ORF2. Regarding the ORF1, SANBAN was only very distantly related to the six major TTV genotypes reported to date. In partial ORF2 sequences determined on 44 isolates taken together, TTV has a broad range of genetic diversity and the SANBAN isolate may represent a new TTV-like viral species or genus and not merely a genotype of TTV.

摘要

关于丁型肝炎病毒（TTV）全基因组的信息一直很少。我们测序的一个变异株（分离株名称为SANBAN）的环状单链DNA基因组与原型分离株（TA278）的同源性仅为56.7%，在氨基酸水平上的同源性更低：ORF1为34.2%，ORF2为39.7%。关于ORF1，SANBAN与迄今为止报道的六种主要TTV基因型的关系非常疏远。在对总共44个分离株测定的部分ORF2序列中，TTV具有广泛的遗传多样性，SANBAN分离株可能代表一种新的TTV样病毒种或属，而不仅仅是TTV的一个基因型。