功能性嗜酸性肾上腺皮质癌
Functional oncocytic adrenocortical carcinoma.
作者信息
Ali Abdullah Essa, Raphael Simon J
机构信息
Department of Pathology, Sunnybrook Health Science Centre, 2075 Bayview Avenue, Room E-432, Toronto, ON, M4N 3M5, Canada.
出版信息
Endocr Pathol. 2007 Fall;18(3):187-9. doi: 10.1007/s12022-007-9000-4.
We present a case of oncocytic adrenocortical carcinoma in a 25-year-old man who presented with persistent hypertension, hypokalemia, and a large right adrenal mass. Clinical workup revealed increased serum aldosterone level, suppressed serum ACTH level and high 24-h urine cortisol. Histologically the tumor showed several features of malignancy and electron microscopy confirmed oncocytic differentiation. This case is reported as the first case of an aldosterone and cortisol-producing malignancy with an oncocytic phenotype.
我们报告一例25岁男性的嗜酸细胞性肾上腺皮质癌，该患者表现为持续性高血压、低钾血症及右侧肾上腺巨大肿块。临床检查发现血清醛固酮水平升高、血清促肾上腺皮质激素水平降低以及24小时尿皮质醇升高。组织学上，肿瘤显示出多种恶性特征，电子显微镜检查证实为嗜酸细胞分化。该病例被报告为第一例具有嗜酸细胞表型的产生醛固酮和皮质醇的恶性肿瘤。
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