Frick M H, Harjola P T, Valle M
Br Heart J. 1975 Apr;37(4):414-9. doi: 10.1136/hrt.37.4.414.
Exercise testing of 52 patients on average 11 months after coronary bypass surgery for the relief of angina pectoris disclosed improvement in total work (P is less than 0.001), maximal tolerated load (P is smaller than 0.001), maximal heart rate (P is smaller than 0.01), and reduction of maximal ST segment depression (P is smaller than 0.001) in a group of 36 patients with all grafts patent. In another group of 16 patients with one or more grafts occluded the only significant change was a reduction in the maximal ST segment depression (P is smaller than 0.01). Early and late postoperative angiograms showed that 75 per cent of the grafts that became occluded were already closed a few weeks after operation. Occluded grafts were accompanied by persistence of collaterals, which disappeared or dimished in the majority of patients with patent grafts. Progression in native vessel lesions occurred in 40 per cent of patients. It was related to the grafting procedure (P is smaller than 0.01) but not to the state of grafts. The change in native vessels and other variables studied was equal in the patent and occluded graft groups, justifying the conclusion that graft patency was the major factor alleviating angina after operation.
对52例冠状动脉搭桥术后平均11个月以缓解心绞痛为目的进行运动试验的患者进行研究发现，在36例所有移植血管通畅的患者中，总功（P＜0.001）、最大耐受负荷（P＜0.001）、最大心率（P＜0.01）均有所改善，最大ST段压低程度降低（P＜0.001）。在另一组16例有1支或多支移植血管闭塞的患者中，唯一显著的变化是最大ST段压低程度降低（P＜0.01）。术后早期和晚期血管造影显示，75%闭塞的移植血管在术后几周内就已闭塞。闭塞的移植血管伴有侧支循环持续存在，而在大多数移植血管通畅的患者中，侧支循环消失或减少。40%的患者出现自身血管病变进展。这与移植手术操作有关（P＜0.01），但与移植血管状态无关。自身血管及其他研究变量的变化在移植血管通畅组和闭塞组中相同，这证明移植血管通畅是术后缓解心绞痛的主要因素这一结论是合理的。
