Serruys P W, Rousseau M F, Cosyns J, Ponlot R, Brasseur L A, Detry J M
Br Heart J. 1978 Nov;40(11):1205-15. doi: 10.1136/hrt.40.11.1205.
Fifty patients underwent an objective measurement of physical working capacity by means of a multistage test of maximally tolerated exertion before and after coronary bypass surgery; 29 patients also had haemodynamic measurements during maximal exercise before and after coronary bypass surgery. The patients were divided into 3 groups according to the degree of revascularisation: adequate (n = 20), partial (n = 17), or none (n = 13). Adequate revascularisation induces a large increase in physical working capacity because of an increased maximal heart rate and maximal cardiac output; stroke volume during maximal exercise and ejection fraction at rest were not modified, suggesting no major changes in left ventricular function. After unsuccessful coronary bypass surgery, the physical working capacity was unchanged despite an increased maximal heart rate; maximal cardiac output was unchanged and stroke volume during maximal exercise was significantly lower. These undesirable results are often associated with perioperative myocardial infarction and are attended by a decreased ejection fraction at rest; these data suggest an impaired left ventricular function after unsuccessful coronary bypass surgery. The results of partial revascularisation are intermediate but appear to be determined by the incidence of partial graft failure which is also often associated with perioperative myocardial infarction. From individual changes in data collected during maximal exercise testing, it is often impossible to predict the degree of revascularisation.
50例患者在冠状动脉搭桥手术前后通过最大耐受运动的多级测试对体力工作能力进行了客观测量;29例患者在冠状动脉搭桥手术前后的最大运动期间还进行了血流动力学测量。根据血运重建程度,患者被分为3组:充分血运重建组(n = 20)、部分血运重建组(n = 17)或无血运重建组(n = 13)。充分血运重建可使体力工作能力大幅提高,这是由于最大心率和最大心输出量增加;最大运动时的每搏输出量和静息射血分数未改变,提示左心室功能无重大变化。冠状动脉搭桥手术失败后,尽管最大心率增加,但体力工作能力未改变;最大心输出量未改变,最大运动时的每搏输出量显著降低。这些不良结果常与围手术期心肌梗死相关,且静息射血分数降低;这些数据提示冠状动脉搭桥手术失败后左心室功能受损。部分血运重建的结果介于两者之间,但似乎取决于部分移植失败的发生率,而部分移植失败也常与围手术期心肌梗死相关。从最大运动测试期间收集的数据的个体变化来看,往往无法预测血运重建的程度。