Rubin R H, Austen K F, Goetzl E J
J Infect Dis. 1975 May;131 Suppl:S98-103. doi: 10.1093/infdis/131.supplement.s98.
A 25-year-old white female returned from West Africa with a two-year history of epidosic swelling, pruritus, and pain in a wrist, associated with peripheral eosinophilia. Serologic and immediate skin tests with Dirofilaria immitis antigen were positive, and blood smears transiently showed microfilariae of Acanthocheilonema perstans after the patient had been treated with diethylcarbamazine. Before treatment, both the serum concentration of IgE and the eosinophil content of arylsulfatase, an enzyme that selectively inactivates slow-reacting substance of anaphylaxis, were elevated; the patient's peripheral leukocytes released histamine and eosinophil chemotactic factor of anaphylaxis when challenged with D. immitis antigen. After one course of diethylcarbamazine, the clinical manifestations and abnormal in vitro immunologic results resolved. Host response to A. perstans infection appears to involve both IgE-mediated hypersensitivity and alterations in an eosinophil enzyme.
一名25岁的白人女性从西非归来，有两年手腕间歇性肿胀、瘙痒和疼痛的病史，伴有外周嗜酸性粒细胞增多。用犬恶丝虫抗原进行的血清学和即刻皮肤试验呈阳性，在用乙胺嗪治疗该患者后，血液涂片短暂显示出常现棘唇线虫的微丝蚴。治疗前，血清IgE浓度和芳基硫酸酯酶（一种选择性灭活过敏反应慢反应物质的酶）的嗜酸性粒细胞含量均升高；当用犬恶丝虫抗原攻击时，患者的外周白细胞释放组胺和过敏反应嗜酸性粒细胞趋化因子。经过一个疗程的乙胺嗪治疗后，临床表现和体外免疫异常结果均消失。宿主对常现棘唇线虫感染的反应似乎涉及IgE介导的超敏反应和嗜酸性粒细胞酶的改变。
