头颈部癌症患者颌骨放射性骨坏死中的机会性放线菌病：发病率及临床意义
Opportunistic actinomycosis in osteoradionecrosis of the jaws in patients affected by head and neck cancer: incidence and clinical significance.
作者信息
Curi M M, Dib L L, Kowalski L P, Landman G, Mangini C
机构信息
Departamento de Estomatologia, Centro de Tratamento e Pesquisa Hospital do Câncer A.C. Camargo, Rua Professor Antonio Prudente, 211, 01509-900 Liberdade, São Paulo, Brazil.
出版信息
Oral Oncol. 2000 May;36(3):294-9. doi: 10.1016/s1368-8375(99)00080-9.
Actinomycosis is occasionally an opportunistic infection occurrence in patients with osteoradionecrosis (ORN). A retrospective study (1992-97) of 50 patients with ORN of the jaws was done to evaluate the incidence and its clinical significance in the management of ORN. Actinomycosis was diagnosed in 12% of ORN cases. In 36 of the 50 patients including five cases of actinomycosis, the ORN was considered to be resolved after treatment. The median treatment duration of ORN was significantly longer (P<0.007) in patients with actinomycosis (29.7 months) than those without the disease (13.4 months). In conclusion, bone biopsy should be considered in cases of ORN with unsatisfactory response to its specific therapies, aiming to identify possible opportunistic actinomycosis infection.
放线菌病偶尔会在放射性骨坏死（ORN）患者中作为机会性感染出现。对50例颌骨ORN患者进行了一项回顾性研究（1992 - 1997年），以评估其在ORN治疗中的发生率及其临床意义。在12%的ORN病例中诊断出放线菌病。在包括5例放线菌病患者在内的50例患者中，有36例ORN被认为在治疗后得到缓解。放线菌病患者ORN的中位治疗时间（29.7个月）显著长于无该病患者（13.4个月）（P<0.007）。总之，对于对特定治疗反应不佳的ORN病例，应考虑进行骨活检，以确定是否存在可能的机会性放线菌感染。
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