颌骨坏死患者骨标本中的[具体物种]：组织病理学分析及临床意义

Ibrahim Norliwati, Apandi Nurul Inaas Mahamad, Shuhardi Syafiqah Aina, Ramli Roszalina

Department of Craniofacial Diagnostics & Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia.

Department of Oral & Maxillofacial Surgery, Hospital Canselor Tuanku Muhriz, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur 56000, Malaysia.

Antibiotics (Basel). 2022 Aug 5;11(8):1067. doi: 10.3390/antibiotics11081067.

Medication-related osteonecrosis of the jaw (MRONJ) and osteoradionecrosis (ORN) are two similar bone pathologies in the jaw with different aetiologies. Actinomycosis is a relatively rare oral infection caused by the Gram-positive anaerobe sp. that normally colonizes the oral cavity. Actinomycosis is associated with the pathogenesis of both the MRONJ and ORN, as evident in our cases, and not just as a superficial contaminant. The clinical and histopathological aspects of the cases treated in our centre were also reported with a review of the literature. Clinical implication on the treatment of the cases was highlighted in view of the presence of this microorganism.

药物相关性颌骨坏死（MRONJ）和放射性骨坏死（ORN）是颌骨中两种病因不同但相似的骨病理状况。放线菌病是一种相对罕见的口腔感染，由革兰氏阳性厌氧菌放线菌属引起，该菌通常定植于口腔。如我们的病例所示，放线菌病与MRONJ和ORN的发病机制均有关联，而非仅仅作为一种表面污染物。我们还报告了在我们中心治疗的病例的临床和组织病理学情况，并对文献进行了综述。鉴于这种微生物的存在，强调了对这些病例治疗的临床意义。