呼肠孤病毒基因组转录的调控
Control of transcription of the reovirus genome.
作者信息
Nonoyama M, Millward S, Graham A F
出版信息
Nucleic Acids Res. 1974 Mar;1(3):373-85. doi: 10.1093/nar/1.3.373.
Abstract
The ten double-stranded RNA segments of the reovirus genome are not transcribed at equal frequencies until later times during the course of infection. When an inhibitor of protein synthesis such as cycloheximide was added to infected cells at the beginning of infection, only four of the ten segments were transcribed. By two hr post infection, five and possibly seven of the segments were being transcribed. By four hr post infection all ten segments were being transcribed but not yet at equal relative frequencies. The transcription pattern at intermediate (4 hr) and late (10 hr) times were verified without using cycloheximide. A repressor present in the host cell may be responsible for controlling transcription of the reovirus genome.
摘要
呼肠孤病毒基因组的十条双链RNA片段在感染过程的后期之前转录频率并不相同。在感染开始时向受感染细胞中添加蛋白质合成抑制剂如环己酰亚胺，十条片段中只有四条被转录。感染后两小时，五条甚至可能七条片段正在被转录。感染后四小时，所有十条片段都在被转录，但相对频率仍不相同。在不使用环己酰亚胺的情况下验证了中期（4小时）和后期（10小时）的转录模式。宿主细胞中存在的一种阻遏物可能负责控制呼肠孤病毒基因组的转录。
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