Launer L J, Ross G W, Petrovitch H, Masaki K, Foley D, White L R, Havlik R J
Epidemiology, Demography and Biometry Program, National Institute on Aging, National Institutes of Health, Gateway Building 3C-309, 7201 Wisconsin Avenue, Bethesda, MD 20892, USA.
Neurobiol Aging. 2000 Jan-Feb;21(1):49-55. doi: 10.1016/s0197-4580(00)00096-8.
We studied the association of mid-life blood pressure to late age dementia, specifically Alzheimer's disease and vascular dementia. Data are from the cohort of 3703 Japanese-American men who were followed in the Honolulu Heart Program (HHP;1965-1971), and subsequently re-examined in 1991 for dementia. We assessed the risk (odds ratio (95% CI)) for dementia associated with categories of systolic (SBP) and diastolic blood pressure (DBP), stratified by never/ever treatment with anti-hypertensive medications, and adjusting for age, education, apolipoprotein epsilon allele, smoking and alcohol intake. Among those never treated (57% sample), the risk for dementia was OR 95% CI 3.8 (1.6-8.7) for DBP of 90-94 mm Hg, and 4. 3 (1.7-10.8) for DBP of 95 mmHg and over compared to those with DBP of 80 to 89 mm Hg. Compared to those with SBP of 110 to 139 mm Hg, the risk for dementia was 4.8 (2.0-11.0) in those with SBP 160 mm Hg and higher. Blood pressure was not associated with the risk for dementia in treated men. These results were consistent for Alzheimer's disease and vascular dementia. This study suggests elevated levels of blood pressure in middle age can increase the risk for late age dementia in men never treated with anti-hypertensive medication.
我们研究了中年血压与晚年痴呆症（特别是阿尔茨海默病和血管性痴呆）之间的关联。数据来自于檀香山心脏项目（HHP；1965 - 1971年）中3703名日裔美国男性的队列研究，这些男性随后在1991年接受了痴呆症复查。我们评估了与收缩压（SBP）和舒张压（DBP）类别相关的痴呆症风险（比值比（95%置信区间）），按是否接受过抗高血压药物治疗进行分层，并对年龄、教育程度、载脂蛋白ε等位基因、吸烟和饮酒量进行了调整。在从未接受治疗的人群（样本的57%）中，与舒张压为80至89毫米汞柱的人群相比，舒张压为90 - 94毫米汞柱时痴呆症风险的比值比（95%置信区间）为3.8（1.6 - 8.7），舒张压为95毫米汞柱及以上时为4.3（1.7 - 10.8）。与收缩压为110至139毫米汞柱的人群相比，收缩压为160毫米汞柱及以上的人群患痴呆症的风险为4.8（2.0 - 11.0）。接受治疗的男性中，血压与痴呆症风险无关。这些结果在阿尔茨海默病和血管性痴呆方面是一致的。这项研究表明，中年时血压升高会增加从未接受过抗高血压药物治疗的男性患晚年痴呆症的风险。
