Petrovitch H, White L R, Izmirilian G, Ross G W, Havlik R J, Markesbery W, Nelson J, Davis D G, Hardman J, Foley D J, Launer L J
Honolulu-Asia Aging Study, Kuakini Medical Center, Suite 307, 846 South Hotel Street, Honolulu HI 96813, USA.
Neurobiol Aging. 2000 Jan-Feb;21(1):57-62. doi: 10.1016/s0197-4580(00)00106-8.
Midlife hypertension is associated with later development of cognitive impairment, vascular dementia (VsD), and possibly Alzheimer's disease (AD). Neuropathic cerebrovascular lesions and brain atrophy have been associated with elevated blood pressure (BP), however, to our knowledge there have been no prospective investigations of an association of blood pressure levels measured in midlife with the microscopic lesions of AD. We investigated the relationship of BP level in midlife to development of neurofibrillary tangles (NFT), neuritic plaques (NP), and low brain weight at autopsy among Japanese-American men who were members of the Honolulu Heart Program/Honolulu-Asia aging Study (HHP/HAAS) cohort. The HHP/HAAS is a population-based, longitudinal study of cognitive function and dementia with 36 years of follow-up. Neocortical and hippocampal NFT and NP were counted per mm(2), and fixed brain weight was measured for 243 decedents. Elevated systolic BP, (> or =160 mm Hg) in midlife was associated with low brain weight and greater numbers of NP in both neocortex and hippocampus. Diastolic BP elevation, (> or =95 mm Hg) was associated with greater numbers of NFT in hippocampus. Results indicate that in addition to the accepted association of high BP with neuropathic cerebrovascular lesions, there is a direct relationship with brain atrophy, NP and NFT.
中年高血压与后期认知障碍、血管性痴呆（VsD）以及可能的阿尔茨海默病（AD）的发生有关。神经病理性脑血管病变和脑萎缩与血压（BP）升高有关，然而，据我们所知，尚未有对中年时测量的血压水平与AD微观病变之间关联的前瞻性研究。我们调查了檀香山心脏项目/檀香山-亚洲老年研究（HHP/HAAS）队列中的日裔美国男性中年时的血压水平与尸检时神经原纤维缠结（NFT）、神经炎斑块（NP）以及低脑重量发生之间的关系。HHP/HAAS是一项基于人群的认知功能和痴呆纵向研究，随访时间长达36年。每平方毫米计数新皮质和海马体中的NFT和NP，并测量243名死者的固定脑重量。中年时收缩压升高（≥160毫米汞柱）与低脑重量以及新皮质和海马体中更多的NP有关。舒张压升高（≥95毫米汞柱）与海马体中更多的NFT有关。结果表明，除了公认的高血压与神经病理性脑血管病变的关联外，高血压与脑萎缩、NP和NFT之间还存在直接关系。
