Brand RA
Departments of Orthopaedic Surgery and Biomedical Engineering, University of Iowa, Iowa City.
J Am Acad Orthop Surg. 1997 Oct;5(5):282-291. doi: 10.5435/00124635-199709000-00006.
Proximal femoral and periacetabular osteotomies for the treatment of osteoarthrosis have produced varying clinical results. Because the underlying pathomechanics of osteoarthrosis are not yet fully understood, it is difficult to predict which type of osteotomy will most improve the biomechanical environment in a given situation. Osteotomies result in relatively small changes in joint load (10% to 20% at most), which probably do not govern tissue responses. However, osteotomies do change the distribution of the load (i.e., stresses) and, perhaps more important, stress gradients. These changes in contact and underlying stresses undoubtedly affect cartilage and bone adaptation. It is likely that the magnitude of stress and strain in cartilage and underlying bone can be altered in such a way that more predictable beneficial remodeling will occur. Emerging imaging and computational technologies may allow patient-specific modeling, which should improve the efficacy and durability of repair.
用于治疗专业医学术语翻译可能存在多种表达方式，以下是一种参考译文：
用于治疗骨关节炎的股骨近端和髋臼周围截骨术产生了不同的临床结果。由于骨关节炎的潜在病理力学尚未完全理解，因此很难预测哪种类型的截骨术在特定情况下最能改善生物力学环境。截骨术导致关节负荷相对较小的变化（最多10%至20%），这可能不会主导组织反应。然而，截骨术确实会改变负荷（即应力）的分布，也许更重要的是应力梯度。这些接触和潜在应力的变化无疑会影响软骨和骨的适应性。软骨和下方骨中的应力和应变大小很可能以这样一种方式改变，即会发生更可预测的有益重塑。新兴的成像和计算技术可能允许进行针对患者的建模，这应该会提高修复的效果和耐久性。
