de C Ramos M, Vilares M C, Jacques De Moraes M, Calusni A L, Roscani G N, Picolli Alves E
Clinical Hospital of the State University of Campinas (UNICAMP), School of Medical Sciences, Campinas, São Paulo, Brazil.
Braz J Infect Dis. 2000 Apr;4(2):86-90.
The main species of mycobacteria isolated in 51 patients with acquired immune deficiency syndrome (AIDS) admitted to the Clinical Hospital of UNICAMP (Teaching Hospital) in 1996, were studied retrospectively by recording the isolation site and signs of pathogenesis. Of these isolates, 31 (55%) were M.tuberculosis and 20 (45%) M.avium complex. Strains of M.tuberculosis isolated in 1996, 1997, and 1998, originating from 42 patients who had AIDS, were tested for susceptibility to isoniazid and rifampicin. Of these, 34 (81%) were susceptible to both drugs tested, 4 (10%) were resistant to isoniazid and susceptible to rifampicin, 2 (5%) were susceptible to isoniazid and resistant to rifampicin, and 2 (5%) were resistant to both rifampicin and isoniazid. We conclude that, in Brazil, M. avium complex infections in AIDS are more common than has been previously suggested; i.e., almost as frequent as M.tuberculosis infections. Approximately 20% of M.tuberculosis strains showed resistance to rifampicin and/or isoniazid. Further distribution of information regarding how to treat the disease in AIDS patients is needed.
对1996年入住坎皮纳斯大学临床医院（教学医院）的51例获得性免疫缺陷综合征（AIDS）患者分离出的主要分枝杆菌种类，通过记录分离部位和发病机制迹象进行了回顾性研究。在这些分离株中，31株（55%）为结核分枝杆菌，20株（45%）为鸟分枝杆菌复合群。对1996年、1997年和1998年从42例AIDS患者中分离出的结核分枝杆菌菌株进行了异烟肼和利福平药敏试验。其中，34株（81%）对两种测试药物均敏感，4株（10%）对异烟肼耐药但对利福平敏感，2株（5%）对异烟肼敏感但对利福平耐药，2株（5%）对利福平和异烟肼均耐药。我们得出结论，在巴西，AIDS患者中的鸟分枝杆菌复合群感染比以前认为的更为常见；即几乎与结核分枝杆菌感染一样频繁。约20%的结核分枝杆菌菌株对利福平和/或异烟肼耐药。需要进一步传播有关如何治疗AIDS患者疾病的信息。
