Kotseva K P, De Bacquer D
National Centre of Occupational Diseases, University Hospital Sv. Ivan Rilski, Sofia, Bulgaria.
Occup Med (Lond). 2000 Jan;50(1):43-7. doi: 10.1093/occmed/50.1.43.
The objective of this study was to investigate the effect of occupational exposure to carbon disulphide (CS2) on the total cholesterol, blood pressure and prevalence of coronary heart disease (CHD). A cross-sectional study involving 252 viscose rayon workers and 252 age and sex matched controls was carried out. Depending on the job and specific work place, the CS2 concentrations were between 10 and 64 mg/m3. A cumulative exposure index (CS2 index) was calculated for each worker by multiplying the number of years he had held a particular job with the CS2 concentrations in that job. CHD prevalence among the exposed was higher than among the controls; the difference reaching significance only for highly exposed workers. Cholesterol levels were significantly higher in both highly and moderately exposed groups. In conclusion, the results demonstrated that occupational exposure to CS2 increases total cholesterol and the risk for CHD. While the risk for CHD is increased in workers exposed to high CS2 concentration for many years (CS2 index > or = 300), even the relatively modest exposure (CS2 < 300) may increase the serum cholesterol.
本研究的目的是调查职业性接触二硫化碳（CS2）对总胆固醇、血压和冠心病（CHD）患病率的影响。开展了一项横断面研究，涉及252名粘胶人造丝工人以及252名年龄和性别相匹配的对照者。根据工作岗位和具体工作场所的不同，CS2浓度在10至64毫克/立方米之间。通过将每名工人从事特定工作的年数乘以该工作岗位的CS2浓度，计算出每个工人的累积接触指数（CS2指数）。暴露组的冠心病患病率高于对照组；仅高暴露工人组的差异具有统计学意义。高暴露组和中暴露组的胆固醇水平均显著更高。总之，结果表明职业性接触CS2会增加总胆固醇水平和患冠心病的风险。虽然多年接触高浓度CS2（CS2指数≥300）的工人患冠心病的风险会增加，但即使是相对适度的接触（CS2＜300）也可能会增加血清胆固醇水平。
