Kotseva K, Braeckman L, De Bacquer D, Bulat P, Vanhoorne M
Department of Public Health, Ghent University, Belgium.
Int J Occup Environ Health. 2001 Jan-Mar;7(1):7-13. doi: 10.1179/107735201800339713.
The objectives of this study were to investigate the cardiovascular effects in workers currently exposed to carbon disulfide (CS2) below the threshold limit value (TLV) of 31 mg/m3 and to determine the prevalence of coronary heart disease (CHD) after long-term exposure. 172 men (91 workers exposed to CS2 in a viscose rayon factory and 81 referent workers) were examined using a medical and job history questionnaire, Rose's questionnaire, and electrocardiography at rest, and by measuring blood pressure and serum lipids and lipoproteins. Personal exposures were monitored simultaneously with active sampling and findings were analyzed according to the NIOSH 1600 method. As a result of technical and organizational improvements, personal CS2 exposures were well below the TLV (5.4-13.02 mg/m3). No significant effect of CS2 on blood pressure or lipids (total cholesterol, HDL and LDL cholesterol, triglycerides, and apolipoproteins AI and B) was found, even after allowance for confounding factors. The prevalence of CHD (ECG abnormalities and chest pain) was higher in the viscose rayon workers than in the workers with no exposure but reached statistical significance for men with exposure histories often years and more only (cumulative CS9 index > or = 150 mg/m3, the most highly exposed group). The findings suggest that the coronary risk is increased in workers previously exposed to high CS2 concentrations but not in those exposed to CS2 levels below the current TLV.
本研究的目的是调查当前暴露于低于31毫克/立方米阈限值（TLV）的二硫化碳（CS2）的工人的心血管影响，并确定长期暴露后冠心病（CHD）的患病率。对172名男性（91名在粘胶人造丝工厂接触CS2的工人和81名对照工人）进行了检查，采用了医疗和工作史问卷、罗斯问卷、静息心电图，并测量了血压、血脂和脂蛋白。通过主动采样同时监测个人暴露情况，并根据美国国家职业安全与健康研究所（NIOSH）1600方法分析结果。由于技术和组织改进，个人CS2暴露远低于TLV（5.4 - 13.02毫克/立方米）。即使考虑了混杂因素，也未发现CS2对血压或血脂（总胆固醇、高密度脂蛋白和低密度脂蛋白胆固醇、甘油三酯以及载脂蛋白AI和B）有显著影响。粘胶人造丝工人中冠心病（心电图异常和胸痛）的患病率高于未接触者，但仅在有十年及以上接触史的男性中（累积CS2指数≥150毫克/立方米，暴露程度最高的组）达到统计学显著性。研究结果表明，既往暴露于高浓度CS2的工人冠心病风险增加，但暴露于低于当前TLV水平的CS2的工人则不然。
