Uzoigwe Jacinta C, Prum Thavaleak, Bresnahan Eric, Garelnabi Mahdi
Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, MA, USA.
N Am J Med Sci. 2013 Aug;5(8):445-53. doi: 10.4103/1947-2714.117290.
Outdoor and indoor air pollution poses a significant cardiovascular risk, and has been associated with atherosclerosis, the main underlying pathology in many cardiovascular diseases. Although, it is well known that exposure to air pollution causes pulmonary disease, recent studies have shown that cardiovascular health consequences of air pollution generally equal or exceed those due to pulmonary diseases. The objective of this article is to evaluate the current evidence on the emerging role of environmental air pollutions in cardiovascular disease, with specific focus on the types of air pollutants and mechanisms of air pollution-induced cardiotoxicity. Published literature on pollution was systematically reviewed and cited in this article. It is hoped that this review will provide a better understanding of the harmful cardiovascular effects induced by air pollution exposure. This will help to bring a better understanding on the possible preventive health measures and will also serve regulatory agencies and researchers. In addition, elucidating the biological mechanisms underlying the link between air pollution and cardiovascular disease is an essential target in developing novel pharmacological strategies aimed at decreasing adverse effects of air pollution on cardiovascular system.
室外和室内空气污染会带来重大的心血管风险，并且与动脉粥样硬化有关，而动脉粥样硬化是许多心血管疾病的主要潜在病理基础。尽管众所周知，接触空气污染会导致肺部疾病，但最近的研究表明，空气污染对心血管健康造成的后果通常等同于或超过肺部疾病所造成的后果。本文的目的是评估当前有关环境空气污染在心血管疾病中所起新作用的证据，特别关注空气污染物的类型以及空气污染诱发心脏毒性的机制。本文对已发表的有关污染的文献进行了系统的综述和引用。希望这篇综述能让人更好地理解接触空气污染所导致的有害心血管影响。这将有助于更好地理解可能的预防性健康措施，也将对监管机构和研究人员有所帮助。此外，阐明空气污染与心血管疾病之间联系的生物学机制，是开发旨在减少空气污染对心血管系统不利影响的新型药理学策略的一个重要目标。
