Evans J R
'Glaxo' Department of Ophthalmology Epidemiology, Institute of Ophthalmology (UCL) and Moorfields Eye Hospital, City Road, London, UK, EC1V 2PD.
Cochrane Database Syst Rev. 2000(2):CD000254. doi: 10.1002/14651858.CD000254.
It has been proposed that antioxidants may prevent cellular damage in the retina by reacting with free radicals produced in the process of light absorption.
The objective of this review is to assess the effects of antioxidant vitamin and/or mineral supplementation on the progression of age-related macular degeneration.
The Cochrane Eyes and Vision Group specialised registered, the Cochrane Controlled Trials Register - Central, MEDLINE, the Science Citation Index, and the reference lists of relevant articles were searched. Investigators of included studies were contacted. The most recent searches were performed in December 1999.
All randomised trials comparing an antioxidant vitamin and/or mineral supplement (alone or in combination) to control in people with age-related macular degeneration were included.
The reviewer extracted data and assessed trial quality. Due to the small number of trials identified, and variable methods of collecting and presenting outcome data, no statistical summary measure was calculated.
Four published, two unpublished and two ongoing trials were identified. Published trials to date have been small and results inconsistent. Adverse effects and quality of life for people with age-related macular degeneration have not been addressed.
REVIEWER'S CONCLUSIONS: The question as to whether people with age-related macular degeneration should take antioxidant vitamin or mineral supplements to prevent progression of the disease has not been answered by research to date. The results of ongoing trials are awaited.
有人提出抗氧化剂可通过与光吸收过程中产生的自由基反应来预防视网膜细胞损伤。
本综述的目的是评估补充抗氧化维生素和/或矿物质对年龄相关性黄斑变性进展的影响。
检索了Cochrane眼科与视觉组专门注册库、Cochrane对照试验注册库 - 中心库、MEDLINE、科学引文索引以及相关文章的参考文献列表。联系了纳入研究的研究者。最近一次检索于1999年12月进行。
纳入所有将抗氧化维生素和/或矿物质补充剂（单独或联合使用）与年龄相关性黄斑变性患者的对照进行比较的随机试验。
综述作者提取数据并评估试验质量。由于所确定的试验数量较少，且收集和呈现结果数据的方法各不相同，因此未计算统计汇总指标。
确定了四项已发表、两项未发表和两项正在进行的试验。迄今为止已发表的试验规模较小且结果不一致。年龄相关性黄斑变性患者的不良反应和生活质量尚未得到探讨。
年龄相关性黄斑变性患者是否应服用抗氧化维生素或矿物质补充剂以预防疾病进展这一问题，迄今为止的研究尚未给出答案。正在等待正在进行的试验结果。
