Arheden H, Saeed M, Higgins C B, Gao D W, Ursell P C, Bremerich J, Wyttenbach R, Dae M W, Wendland M F
Department of Radiology, University of California San Francisco, 505 Parnassus Ave, L308, San Francisco, CA 94143-0628, USA.
Radiology. 2000 May;215(2):520-8. doi: 10.1148/radiology.215.2.r00ma38520.
To estimate and compare the fractional distribution volume (fDV) of gadodiamide injection and technetium 99m-diethylenetriaminepentaacetic acid (DTPA) in the reperfused myocardium of rat hearts subjected to various durations of ischemia.
Magnetic resonance (MR) imaging and autoradiography were performed in rats subjected to 20, 30, 40, or 60 minutes of regional ischemia followed by 1 hour of reperfusion. The fDVs of gadodiamide injection and (99m)Tc-DTPA were measured and compared by using inversion-recovery echo-planar imaging and autoradiographic phosphor imaging, respectively.
The mean fDV of both tracers (gadodiamide and (99m)Tc-DTPA) in normal myocardium was 18% +/- 1, whereas that in the entire area at risk increased significantly (P <.05) with 20, 30, 40, and 60 minutes of ischemia to 32% +/- 1, 57% +/- 4, 66% +/- 2, and 68% +/- 2, respectively. The fDV was significantly (P <.05) greater in the core of infarction-78% +/- 4, 89% +/- 5, and 88% +/- 5 with 30, 40, and 60 minutes of ischemia, respectively-than in the normal myocardium or in the area at risk.
The fDV of MR contrast material in the periinfarcted rim was significantly (P <. 05) greater than that in the normal myocardium, but significantly less than that in the core of infarcted myocardium.
评估并比较钆双胺注射液和锝99m-二乙三胺五乙酸（DTPA）在经历不同时长缺血的大鼠心脏再灌注心肌中的分布容积分数（fDV）。
对经历20、30、40或60分钟局部缺血后再灌注1小时的大鼠进行磁共振（MR）成像和放射自显影。分别使用反转恢复回波平面成像和放射自显影磷光成像测量并比较钆双胺注射液和（99m）Tc-DTPA的fDV。
正常心肌中两种示踪剂（钆双胺和（99m）Tc-DTPA）的平均fDV为18%±1%，而随着缺血20、30、40和60分钟，整个危险区域的fDV显著增加（P<.05），分别达到32%±1%、57%±4%、66%±2%和68%±2%。梗死核心区域的fDV显著（P<.05）高于正常心肌或危险区域，缺血30、40和60分钟时分别为78%±4%、89%±5%和88%±5%。
梗死周边区域磁共振对比剂的fDV显著（P<.05）高于正常心肌，但显著低于梗死心肌核心区域。
