Campistol J, Fernández A, Ortega J
Servicio de Pediatría, Hospital Universitari Sant Joan de Déu, Barcelona, España.
Rev Neurol. 1999;29(4):359-65.
The treatment in the acute phase of seizures and status epilepticus is a neurological emergency situation. Aggressive treatment and resuscitation maneuvers against the seizure may be required to avoid progression towards status epilepticus, with the high risk for the patients outcome this involves.
The use of rectal diazepam has supposed a great advance in the management of acute seizures. Intravenous sodium valproate has become available in these last years to control seizures and status epilepticus. Given at 20 mg/kg as single dose and with maintenance rate of 1 mg/kg/hour by intravenous infusion in 19 paediatric patients (1 day-7 years) status epilepticus was controlled in 58%, with reduction of status in 26%. Tolerance was good and there was no evidence of important adverse effects.
In view of our experience, we present a new protocol for the treatment of seizures and status epilepticus in childhood.
癫痫发作和癫痫持续状态急性期的治疗是一种神经科急症。可能需要针对癫痫发作进行积极治疗和复苏措施，以避免进展为癫痫持续状态，因为这会给患者预后带来高风险。
直肠给予地西泮在急性癫痫发作的管理方面取得了重大进展。近年来，静脉注射丙戊酸钠已可用于控制癫痫发作和癫痫持续状态。在19例年龄为1天至7岁的儿科患者中，以20mg/kg单剂量静脉注射，并以1mg/kg/小时的维持速率静脉输注，58%的患者癫痫持续状态得到控制，26%的患者病情有所减轻。耐受性良好，且未发现明显不良反应。
鉴于我们的经验，我们提出了一种治疗儿童癫痫发作和癫痫持续状态的新方案。
