[用于治疗急性惊厥和惊厥持续状态的药物特性]
[Characteristics of drugs used in the treatment of acute convulsions and convulsive status].
作者信息
Herranz J L, Argumosa A
机构信息
Servicio de Neuropediatría, Hospital Universitario Marqués de Valdecilla, Santander, España.
出版信息
Rev Neurol. 2000;31(8):757-62.
OBJECTIVE
To evaluate the pharmacokinetic and pharmacodynamic characteristics of the drugs used in the treatment of acute seizures and status epilepticus.
DEVELOPMENT
After emphasizing the clinical importance of seizure episodes and the pathophysiology of status epilepticus, we describe the ideal characteristics of the drugs used for their treatment. Subsequently we analyze the pharmacokinetic characteristics, efficacy and toxicity of phenobarbitone, phenytoin, diazepam and valproate given parenterally. Although the efficacy of the four drugs is similar when given parenterally, fewer side-effects are seen with valproate.
CONCLUSIONS
Parenteral valproate should be included in the normal guidelines for the treatment of convulsions. In this paper we include the recommended measures for the treatment of acute seizures and status epilepticus in childhood and suggest the development of similar measures for adult patients.
目的
评估用于治疗急性惊厥和癫痫持续状态的药物的药代动力学和药效学特征。
进展
在强调惊厥发作的临床重要性和癫痫持续状态的病理生理学之后，我们描述了用于治疗的药物的理想特征。随后，我们分析了静脉注射苯巴比妥、苯妥英、地西泮和丙戊酸盐的药代动力学特征、疗效和毒性。尽管这四种药物静脉注射时疗效相似，但丙戊酸盐的副作用较少。
结论
静脉注射丙戊酸盐应纳入惊厥治疗的常规指南。在本文中，我们纳入了儿童急性惊厥和癫痫持续状态治疗的推荐措施，并建议为成年患者制定类似的措施。
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