Kirn-Safran C B, Carson D D
Department of Biological Sciences, University of Delaware, Newark 19716, USA.
Semin Reprod Endocrinol. 1999;17(3):217-27. doi: 10.1055/s-2007-1016229.
Embryo attachment to the apical surface of the uterine epithelium is an event found in all mammalian species. Consequently, aspects of this process may be shared and considered as general principles in implantation strategies across species. This review focuses on studies implicating mucin glycoproteins disposed at the apical surface of uterine epithelia as antiadhesive molecules that block embryo attachment. As such, mucins must be removed, at least locally, to permit intimate contact between trophectoderm and uterine epithelia. Subsequently, we consider the role that heparan sulfate proteoglycans (HSPGs) and HSPG-binding proteins play in tethering embryos to the apical surface of uterine epithelia during the attachment process.
胚胎附着于子宫上皮的顶端表面是所有哺乳动物物种都会出现的现象。因此，这一过程的某些方面可能具有共性，可被视为跨物种着床策略的一般原则。本综述聚焦于一些研究，这些研究表明位于子宫上皮顶端表面的黏蛋白糖蛋白作为抗黏附分子会阻碍胚胎附着。因此，黏蛋白必须至少在局部被清除，以使滋养外胚层与子宫上皮能够紧密接触。随后，我们探讨硫酸乙酰肝素蛋白聚糖（HSPGs）和HSPG结合蛋白在胚胎附着过程中使胚胎附着于子宫上皮顶端表面所起的作用。
