Zhang K, Tarazi F I, Baldessarini R J
Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA.
Neuroscience. 2000;97(2):211-3. doi: 10.1016/s0306-4522(00)00082-8.
Dopamine D(2) receptors are implicated in stimulant-induced behavioral sensitization.(7,10) Studies using selective receptor antagonists also implicate the D(4) receptor, a member of the dopamine D(2)-like receptor family.(3) Accordingly, dopamine D(4) and D(2)-like receptor levels in rat forebrain were examined by computed autoradiography after repeated (+)-amphetamine treatment that induced behavioral sensitization. Receptor binding was quantified in critical brain regions including caudate-putamen, nucleus accumbens septi, medial prefrontal cortex and hippocampus. No significant differences in D(4) or D(2)-like receptor levels were detected among rats sensitized to amphetamine, those exposed to amphetamine but killed before behavioral sensitization emerged or vehicle-treated controls. The findings indicate that expression of amphetamine-induced behavioral sensitization is not associated with altered D(4) (or D(2)) receptor density in rat forebrain.
多巴胺D(2)受体与兴奋剂诱导的行为敏化有关。(7,10) 使用选择性受体拮抗剂的研究也表明多巴胺D(4)受体（多巴胺D(2)样受体家族的一员）与之有关。(3) 因此，在重复给予(+)-苯丙胺诱导行为敏化后，通过计算机放射自显影术检测大鼠前脑多巴胺D(4)和D(2)样受体水平。在包括尾状核-壳核、伏隔核、内侧前额叶皮质和海马体在内的关键脑区对受体结合进行定量分析。在对苯丙胺敏感的大鼠、接触过苯丙胺但在行为敏化出现前处死的大鼠或接受赋形剂处理的对照组之间，未检测到D(4)或D(2)样受体水平的显著差异。研究结果表明，苯丙胺诱导的行为敏化的表达与大鼠前脑D(4)（或D(2)）受体密度的改变无关。
