Tarazi F I, Tomasini E C, Baldessarini R J
Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02178, USA.
Brain Res Dev Brain Res. 1998 Oct 1;110(2):227-33. doi: 10.1016/s0165-3806(98)00111-4.
Development of dopamine D4-like receptors in rat caudate-putamen (CPu), nucleus accumbens (NAc), frontal cortex, hippocampus, and entorhinal cortex was assessed at seven points between postnatal days 7 and 60 by computed in vitro receptor autoradiography, and compared with dopamine (DA) D2-like receptors. Density of radioligand binding to both receptor types increased from day 7 to a peak at day 28 in caudate-putamen (D4, 3.3-fold; D2, 4.3-fold) and nucleus accumbens (2.9- and 3.6-fold), then declined by 28%-33% over days 35-60 to adult levels in both brain regions. In hippocampus, frontal and entorhinal cortex, both receptor types increased by 3.8- to 5.8-fold from day 7 to maximal levels at day 35 that remained unchanged to day 60. These findings suggest: (1) D4- and D2-like receptors follow a similar course of development in several cortical, extrapyramidal, and limbic regions of rat forebrain; (2) elimination of excessive receptors of both types occurred in caudate-putamen and nucleus accumbens but not in the other brain regions.
通过体外计算机受体放射自显影技术，在出生后第7天至60天之间的7个时间点评估大鼠尾状核-壳核（CPu）、伏隔核（NAc）、额叶皮质、海马体和内嗅皮质中多巴胺D4样受体的发育情况，并与多巴胺（DA）D2样受体进行比较。在尾状核-壳核（D4为3.3倍；D2为4.3倍）和伏隔核（2.9倍和3.6倍）中，两种受体类型的放射性配体结合密度从第7天增加到第28天达到峰值，然后在第35 - 60天下降28% - 33%至成年水平。在海马体、额叶皮质和内嗅皮质中，两种受体类型从第7天到第35天增加3.8至5.8倍达到最大水平，并持续到第60天保持不变。这些发现表明：（1）D4样和D2样受体在大鼠前脑的几个皮质、锥体外系和边缘区域遵循相似的发育过程；（2）尾状核-壳核和伏隔核中两种类型的过量受体被清除，但其他脑区没有。
