L-肼基-α-甲基多巴（MK-486）作用后血液中5-羟吲哚乙酸的来源
The origin of blood 5-hydroxyindoleacetic acid following L-hydrazine-alpha-methyldopa (MK-486).
作者信息
Warsh J J, Stancer H C
出版信息
Eur J Pharmacol. 1975 May;32(1):128-32.
Blood 5-HIAA-14C levels derived from exogenous D,L-5-HTP-14C were investigated in normal, sham-operated and nephrectomized rats pretreated with MK-486 and probenecid (200 mg/kg i.p.). Blood 5-HIAA-14C levels decreased in nephrectomized rats following probenecid. Peripheral decarboxylase inhibition by MK-486 was enhanced by both probenecid and nephrectomy. Increased penetration of 5-HTP into brain occurred following probenecid. Thr results indicate that the following MK-486 about 20% of the blood 5-HIAA-14C derived from 5-HTP-14C in rats originates in the CNS.
在预先用MK - 486和丙磺舒（200mg/kg腹腔注射）处理的正常大鼠、假手术大鼠和肾切除大鼠中，研究了源自外源性D，L - 5 - 羟色氨酸 - 14C的血液5 - 羟吲哚乙酸 - 14C水平。丙磺舒处理后，肾切除大鼠的血液5 - 羟吲哚乙酸 - 14C水平降低。丙磺舒和肾切除均增强了MK - 486对外周脱羧酶的抑制作用。丙磺舒处理后，5 - 羟色氨酸进入脑内的渗透性增加。结果表明，在大鼠中，服用MK - 486后，源自5 - 羟色氨酸 - 14C的血液5 - 羟吲哚乙酸 - 14C约20%起源于中枢神经系统。
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