He W, Parker R
Department of Molecular and Cellular Biology, Howard Hughes Medical Institute, University of Arizona, Tucson 85721, USA.
Curr Opin Cell Biol. 2000 Jun;12(3):346-50. doi: 10.1016/s0955-0674(00)00098-3.
Recent results have identified a family of Lsm (Like Sm) proteins that are related to the Sm protein family. Seven Lsm proteins form a complex, which interacts with the U6 snRNA and functions in splicing. In addition, a different complex of Lsm proteins interacts with cytoplasmic mRNA and promotes its turnover. These diverse functions of Lsm proteins suggest that they are important modulators of RNA biogenesis and function.
最近的研究结果鉴定出了一类与Sm蛋白家族相关的Lsm（类Sm）蛋白。七种Lsm蛋白形成一个复合体，该复合体与U6小核RNA相互作用并在剪接过程中发挥作用。此外，一种不同的Lsm蛋白复合体与细胞质信使核糖核酸相互作用并促进其周转。Lsm蛋白的这些多样功能表明它们是RNA生物合成和功能的重要调节因子。
