Emri S, Kocagoz T, Olut A, Güngen Y, Mutti L, Baris Y I
Hacettepe Medical Faculty, Ankara, Turkey.
Anticancer Res. 2000 Mar-Apr;20(2A):891-4.
Malignant pleural mesothelioma (MPM) continues to be a public health problem in Turkey, where exposure to environmental asbestos and fibrous zeolite (erionite) is the main cause of the disease. However, less than 5% of exposed individuals develop the disease, and numerous cases of MPM are documented each year in which the patient has no known exposure to either of these minerals. Thus, additional unknown factors act independently or as co-carcinogens in the development of MPM. Simian Virus 40 (SV40) may act as a co-carcinogen with asbestos in the pathogenesis of occupationally induced MPM. To determine if SV40 plays a role in the development of MPM in Turkey, we used PCR analysis to investigate if SV40 DNA sequences were present in 29 mesothelioma specimens from patients previously exposed to asbestos or erionite. PCR analysis revealed that all 29 tissue specimens from our patients did not contain SV40 DNA. 15 specimens from patients suffering from tuberculosis pleuresy were also SV40 negative. One mesothelioma and one osteosarcoma from Italy tested positive for SV40. Our results indicate that inorganic fibers, asbestos, and erionite remain the only known causal factors of mesothelioma in Turkey. The absence of SV40 in Turkish specimens and its presence in Italian specimens may be related to the fact that SV40-contaminated vaccines were not administered in Turkey.
恶性胸膜间皮瘤（MPM）在土耳其仍然是一个公共卫生问题，在该国，接触环境中的石棉和纤维沸石（毛沸石）是该疾病的主要病因。然而，接触者中不到5%会患上这种疾病，而且每年都有大量MPM病例记录在案，其中患者并无已知的这两种矿物质接触史。因此，其他未知因素在MPM的发生发展过程中独立起作用或作为共致癌物起作用。猿猴病毒40（SV40）在职业性诱发的MPM发病机制中可能与石棉共同作为致癌物。为了确定SV40在土耳其MPM发生过程中是否起作用，我们采用聚合酶链反应（PCR）分析来研究29例曾接触石棉或毛沸石的患者的间皮瘤标本中是否存在SV40 DNA序列。PCR分析显示，我们患者的所有29个组织标本均不含有SV40 DNA。15例结核性胸膜炎患者的标本也为SV40阴性。来自意大利的1例间皮瘤和1例骨肉瘤检测出SV40呈阳性。我们的结果表明，无机纤维、石棉和毛沸石仍然是土耳其间皮瘤仅有的已知致病因素。土耳其标本中不存在SV40而意大利标本中存在SV40，这可能与土耳其未接种受SV40污染的疫苗这一事实有关。
