Wang Rui-An
State Key Lab for Cancer Biology, Department of Pathology, Xijing Hospital, Xi'an, China,
Cancer Metastasis Rev. 2014 Dec;33(4):1001-9. doi: 10.1007/s10555-014-9525-1.
Gene mutation's role in initiating carcinogenesis has been controversial, but it is consensually accepted that both carcinogenesis and cancer metastasis are gene-regulated processes. MTA1, a metastasis-associated protein, has been extensively researched, especially regarding its role in cancer metastasis. In this review, I try to elucidate MTA1's role in both carcinogenesis and metastasis from a different angle. I propose that MTA1 is a stress response protein that is upregulated in various stress-related situations such as heat shock, hypoxia, and ironic radiation. Cancer cells are mostly living in a stressful environment of hypoxia, lack of nutrition, and immune reaction attacks. To cope with all these stresses, MTA1 expression is upregulated, plays a role of master regulator of gene expression, and helps cancer cells to survive and migrate out of their original dwelling.
基因突变在引发癌变过程中的作用一直存在争议，但人们普遍认为，癌变和癌症转移都是基因调控的过程。转移相关蛋白1（MTA1）已得到广泛研究，尤其是其在癌症转移中的作用。在这篇综述中，我试图从不同角度阐明MTA1在癌变和转移中的作用。我提出，MTA1是一种应激反应蛋白，在热休克、缺氧和铁离子辐射等各种与应激相关的情况下会上调表达。癌细胞大多生活在缺氧、缺乏营养和免疫反应攻击的应激环境中。为了应对所有这些应激，MTA1的表达上调，发挥基因表达主调节因子的作用，并帮助癌细胞存活并迁移出其原始驻留地。
