高效钯催化的吲哚N-芳基化反应
Efficient palladium-catalyzed N-arylation of indoles.
作者信息
Old D W, Harris M C, Buchwald S L
机构信息
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
出版信息
Org Lett. 2000 May 18;2(10):1403-6. doi: 10.1021/ol005728z.
PMID:10814458
Abstract
[equation--see text] The N-arylation of indoles, including a variety of substituted ones, has been carried out using bulky, electron-rich phosphines as the supporting ligand in combination with Pd(2)(dba)(3). Using this catalyst system, the efficient coupling of indole and a variety of substituted indoles with aryl iodides, bromides, chlorides, and triflates can be achieved.
摘要
[方程式——见正文] 吲哚的N-芳基化反应，包括各种取代的吲哚，已使用体积庞大、富电子的膦作为辅助配体与Pd₂(dba)₃结合进行。使用该催化体系，可以实现吲哚和各种取代吲哚与芳基碘化物、溴化物、氯化物和三氟甲磺酸酯的有效偶联。
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