钯催化的N-取代吲哚与1-芳基三氮烯的直接C2芳基化反应。
Palladium-catalyzed direct C2 arylation of N-substituted indoles with 1-aryltriazenes.
作者信息
Liu Can, Miao Tao, Zhang Lei, Li Pinhua, Zhang Yicheng, Wang Lei
机构信息
Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000 (P.R. China), Fax: (+86) 561-3090518.
出版信息
Chem Asian J. 2014 Sep;9(9):2584-9. doi: 10.1002/asia.201402274. Epub 2014 Jun 11.
A novel and efficient palladium-catalyzed C2 arylation of N-substituted indoles with 1-aryltriazenes for the synthesis of 2-arylindoles was developed. In the presence of BF3⋅OEt2 and palladium(II) acetate (Pd(OAc)2), N-substituted indoles reacted with 1-aryltriazenes in N,N-dimethylacetamide (DMAC) to afford the corresponding aryl-indole-type products in good to excellent yields.
开发了一种新颖且高效的钯催化N-取代吲哚与1-芳基三氮烯的C2芳基化反应，用于合成2-芳基吲哚。在三氟化硼乙醚（BF3⋅OEt2）和醋酸钯（Pd(OAc)2）存在下，N-取代吲哚与1-芳基三氮烯在N,N-二甲基乙酰胺（DMAC）中反应，以良好至优异的产率得到相应的芳基吲哚类产物。
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