氟代和氯代芳烃的碱促进反应： -芳基吲哚和咔唑的合成途径。
Base-Promoted Reactions of Fluoro- and Chloroarenes as a Route to -Aryl Indoles and Carbazoles.
机构信息
Key Laboratory of Organic Optoelectronics & Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
出版信息
Molecules. 2019 Mar 22;24(6):1145. doi: 10.3390/molecules24061145.
Abstract
KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution () between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding -arylated indoles and carbazoles has been developed.
摘要
KOH/DMSO 促进的亲核芳香取代反应（SNAr）在无过渡金属条件下，实现了氯代芳烃或氟代芳烃与吲哚和咔唑之间的 C-N 键形成，生成相应的芳基化吲哚和咔唑化合物。
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